EggCentris is a centre of excellence for reproductive health assessment.
As a contract research laboratory specialised in the analysis of the reproductive function, we offer question-directed project research and have developed a unique battery of innovative multi-parametric long-term in-vitro bioassays to assess female and male fertility and embryo toxicity.
Evaluation of a compounds effect on reproductive health is a major issue in the REACH legislation. For most substances insufficient information is available.
For hazard identification and characterisation, the use of an intelligent integrated testing approach including appropriate in vitro methods will be the only way to cope with the demands.
Products and services:
- Question-directed project research:
Design and execution of projects to characterise reproductive toxicants (Expertise, in-vivo, ex-vivo and in-vitro studies). - In-Vitro test batteries:
These in vitro bioassays are ideal to define safety levels at the target organ and for ranking compounds within a chemical class.
Our in vitro bioassays closely mimic the in-vivo physiology; only require minute’s amounts of product to generate in a short time qualitative and quantitative data typifying a compound’s impact on reproductive health.
Female fertility:
FBA (Follicle Bioassay; assessment of ovarian cycle, steroidogenesis/endocrine disruption, oocyte development)
IVM (In vitro maturation; assessment of the meiotic process)
IVF (In vitro fertilisation; functional assessment of gamete (oocyte/sperm) quality
MEA (Mouse Embryo Assay; assessment of pre-implantation embryo developmental capacity)
Male fertility:
Leydig and Primary Sertoli cell cultures for the evaluation of testicular toxicity and endocrine disruption.
Sperm analysis (viability, motility and functional analysis).
Embryo toxicity:
MEPA (mouse peri-implantation assay; analyses pre-implantation embryo development and survival capacity upon implantation)
EST (Embryonic Stem cell Test, ECVAM validated test, predicting the embryo toxicity of compounds)
Website: http://www.eggcentris.com/